When aliens launch an assault on New York City, the most powerful heroes and villains in the Marvel Universe band together to stop the invasion. A single-player story mode and a single- or two-player vs. mode are available in Marvel Nemesis. In the single-player story mode, players fight through a Mark Millar-scripted scenario. In contrast, in the single- or two-player versus mode, heroes and villains compete against each other in a sandbox arena.
The artist Jae Lee has recreated several well-known Marvel characters, and brand-new characters have been designed specifically for this game series. All versions have unlockable venues, characters, and extras, except the PS2 and Xbox versions, which feature online play.